Cathepsin G Inhibitor I 16895 The mean antiproliferative activity IC50

The mean antiproliferative activity IC50 values determined against nine human cancer cell lines investigated (using the MTT colorimetric assay) were 19

1'-biphenyl]-4-yl}ethoxy)pyrimidin-4-yl]phenyl}propanoic acid

ASPA is related to the inhibition of inflammatory cytokines (TNF-α

but most patients progress to a more aggressive form of the disease named castration-resistant prostate cancer

Smiles: CC1=CC(NC2N=CC(Cl)=C(NC3=CC=CC=C3S(=O)(=O)C(C)C)N=2)=C(C=C1C1CCNCC1)OC(C)C

Cathepsin G Inhibitor I 16895 The mean antiproliferative activity IC50IC50: 53 nM Cathepsin G (EC 3. 4. 21. 20, chymotrypsin like proteinase, neutral proteinase) is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non peptide inhibitor of cathepsin G. In vitro: Cathepsin G Inhibitor I shows reversible, competitive inhibition with IC50 and Ki values of 53 12 (N = 10) and 63 14 nM (N = 5),