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Formula: C24H30N8O
25-100 mg/kg
8 nM and a Ki of 4
InChiKey: YHGSTSNEOJUIRN-UHFFFAOYSA-N
MIK665 (S-64315) inhibits H929 cell with an IC50 of 250 nM
JTE-607 394Methyl Atorvastatin hemicalcium Formula: C24H30N8OJTE 607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE 607 inhibits inflammatory cytokine production, including TNF , IL 1, IL 6, IL 8 and IL 10, from LPS stimulated human PBMCs, with IC50s of 11, 5. 9, 8. 8, 7. 3 and 9. 1 nM, respectively. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE 607. Product information CAS Number: 188791 09 5 Molecular Weight: 597. 36