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InChiKey: ORZHZQZYWXEDDL-UHFFFAOYSA-N
with EC50s of 330 nM
which was initially accompanied by increases in body temperature and heart rate that abated with continued dosing
) also reverses abnormality of serum metabolome
Akiyama T E
PD-166793 2265 InChiKey: ORZHZQZYWXEDDL-UHFFFAOYSA-NPD 166793 is a potent, selective, orally active and widebroad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP 2, MMP 3 and MMP 13 (IC50=4, 7, and 8 nM, respectively) and micromolar potency vs MMP 1, 7 and 9 (IC50=6. 0, 7. 2, and 7. 9 M, respectively). PD 166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Product information CAS Number: 199850 67 4 Molecular Weight: 412. 30
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