If an opponent is at 40 life, and takes a hit from Astarion with the Spike equipped, they will lose four life from combat damage, putting them to 36, and then half of that from Quietus Spike, dropping them to 18, for a total of 22 points of life lost
Some stores have a decent stock near the checkout aisles or in the toy section, while others might not carry them at all
We already had the much maligned board wipe of Be Prepared, the classic Dragon Fire for targeted removal and recently Lady Tremaine has been forcing players to banish one of their own characters when she enters play, even getting around ward effects
If an effect modifies a creature's power and/or toughness without setting them, that is not included when determining its base power and toughness
I played my Incremental Growth, which got countered by Yetka's Familiars Ruse bouncing his Brion Stoutarm, making Guile a 9/9 and Berryman's treefolk even more formidable walls