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There are tons of other synergistic engines like Goblin Welder, Daretti, Scrap Savant, and Goblin Engineer to fit in all kinds of combos and interactions into the list

Of course, if a player has an instant spell with enough untapped mana or a mana ability on a card already on the battlefield, the aftermath spell can be thwarted in some way

The efficiency of your combo is a question of how many pieces there are to your puzzle and how easy those pieces are to assemble

By default you cast them at sorcery speed (your own main phase when the stack is empty) but many have flash to jump in as surprises

Pumping more mana into flickering or cloning Agent of Treachery is a win condition in many decks