defiler cards mtg MTGNexus This effect reduces only the amount of red mana you pay Dread Defiler – Slawomir Maniak

It may not be the most interesting new card, but its certainly one of the most effective.

One example of a generically useful card is Tesak, Judiths Hellhound

Archangel Japanese Media Promo Market Price: $69.69 Featuring one-off artwork by Donato Giancola, this card was included as a media insert in a Japanese magazine around the release of Sixth Edition in 1999

Yes there have been sets which feature other planes (Mercadia, Rath, Serras realm, The Homelands) but they were always connected at least tangentially to Dominaria

Finally, Karvanista, Loyal Lupari helps humans both as a creature and as a sorcery adventure, be it for protection or for +1/+1 counters