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I think this is a more non-conditional removal spell you'll want in your deck as opposed to Elspeth's Smite

One mana to stop a combo piece or board wipe is a bargain every time

You could also theme a Humans deck around your favourite plane because odds are it features Humans (unless you're a big Lorwyn fan)

Likewise, Orchish Bowmasters is a great new black EDH staple that does the same kind of work here as Lotho, namely via punishing opponents who are trying to do too much by pinging any target and providing creature tokens that can end up doubled if you dont already have one

If you do, create a token that's a copy of that creature, except it's 1/1 and has toxic 1