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423(3):376-80
Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer
(2012) Proc Natl Acad Sci U S A
InChi: InChI=1S/C32H35N5O5/c1-42-26-15-9-23(10-16-26)32(17-5-2-6-18-32)21-34-30(38)29(19-22-20-33-28-8-4-3-7-27(22)28)36-31(39)35-24-11-13-25(14-12-24)37(40)41/h3-4
Administration of 1 mg/kg
NVP-ADW742 Catalog No.:M7898-10 423(3):376-80NVP ADW742, also known as ADW 742 or GSK 552602A, is a novel small weight molecular inhibitor of IGF IR with potential anticancer activity. NVP ADW742 inhibited IGF IR mediated proliferation with an IC50 of 11. 12 mol l. NVP ADW742 induced early suppression of Akt, P38 and GSK 3 phosphorylation. NVP ADW742 enhanced the chemosensitivity of Daoy to temozolomide in vitro, as a potent anti tumor agent highly selective against IGF IR. NVP ADW742 was found