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You can either run that creature into blockers, or sacrifice it to one of your own abilities for a benefit

Weatherlight Compleated is a possible exception

Neither of these are things you would actually want to do, but that's just the nature of trying to find things to do with cards with effects like this

You could buy one of the precons and add the Dungeons & Dragons Players Handbook to your cart, or you can buy the four decks and add a D&D Essentials Kit

The Porygon from Base set, literally as old as it gets, has an attack called Conversion 1: if the Defending Pokmon has a Weakness, you can change it to any type but colorless