While Pestilence had a knack for picking off smaller creatures with Regeneration back in the day, if you had a large enough regenerator or a creature with Protection from Black, it could circumvent the trigger
Or, make cards of your friends
Given that each Pokmon Tool can be attached to a different Pokmon, and any number of Item cards can be played on a turn, this can really buff a players Active and Benched Pokmon, pretty much instantly
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Another point of interest are booster boxes, which are boxes with many booster packs inside them