Palbociclib-propargyl 314entane-1 5-diamine dihydrochloride Smiles: COC1=CC(=NC(NC(=O)NS(=O)(=O)C2=NC=CC=C2C(=O)N(C)C)=N1)OC

Smiles: COC1=CC(=NC(NC(=O)NS(=O)(=O)C2=NC=CC=C2C(=O)N(C)C)=N1)OC

13-heptaen-12-one

CC1C=CC(=CC=1)C(=O)CN1C(=N)SC2CCCCC1=2

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1

InChiKey: RSMZOLWJZGIWOV-CZIZESTLSA-N

Palbociclib-propargyl 314entane-1 5-diamine dihydrochloride Smiles: COC1=CC(=NC(NC(=O)NS(=O)(=O)C2=NC=CC=C2C(=O)N(C)C)=N1)OCPalbociclib propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP 10. CP 10 shows a DC50 of 2. 1 nM for CDK6. Product information CAS Number: 2366269 23 8 Molecular Weight: 485. 58 Formula: C27H31N7O2 Chemical Name: 6 acetyl 8 cyclopentyl 5 methyl 2 ({5 [4 (prop 2 yn 1 yl)piperazin 1 yl]pyridin 2 yl}amino) 7H,8H pyrido[2,3 d]pyrimidin 7 one Smiles: