TL13-12 idine isethionate and Aurora B with slightly

and Aurora B with slightly lower potency

Solubility: DMSO: 42 mg/mL(98

Vacuolin-1 is also a potent and selective PIKfyve inhibitor

Inhibitors of activin receptor-like kinase

Ro 5126766 effectively inhibits activation of ERK2 by MEK1 with an IC50 of 160 nM (SD=±0

TL13-12 idine isethionate and Aurora B with slightlyTL13 12 is a potent and selective ALK PROTAC degrader and inhibits ALK activity with an IC50 value of 0. 69 nM. TL13 12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13. 5 nM, 5. 74 nM, 18. 4 nM, and 65 nM, respectively. TL13 12 is comprised of the conjugation of TAE684 (HY 10192) and the cereblon ligand of Pomalidomide (HY 10984). Product information CAS Number: 2229037 04 9