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Dainichi T
CAS Number: 2070015-00-6
ML216 also inhibits cell proliferation of BLM-proficient fibroblast cells (PSNF5) while having only minimal effects on BLM-deficient fibroblast cells (PSNG13)
InChiKey: XMAYWYJOQHXEEK-OZXSUGGESA-N
2012 Oct 25
Geldanamycin 0565 Dainichi TGeldanamycin is a benzoquinone ansamycin antibiotic that binds to Hsp90 (Heat Shock Protein 90) and inhibits its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis. Hsp90 geldanamycin complex. PDB 1yet Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v Src, Bcr Abl and p53 preferentially over their normal
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