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In the drug-resistant NSCLC cell line H1975
PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling
Smiles: [2H]C([2H])([2H])C(CCC[C@@H](C)[C@H]1CC[C@H]2/C(/CCC[C@@]21C)=C/C=C1/C[C@@H](O)CCC/1=C)C([2H])([2H])[2H]
RFRP-3 (Neuropeptide VF(124-131))(human)
In cultured human cancer cells
Ibudilast-d3 azole D3 In the drug-resistant NSCLC cellIbudilast d3 (KC 404 d3) is the deuterium labeled Ibudilast. Ibudilast (KC 404) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti dementia agent counteracting neurotoxicity in activated microglia. Product information CAS Number: 102064