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Sirt2-PROTAC-1 is a SirReal based PROTAC
Knockdown of DR4 abolishes NF-κB activation
6(9):e23943
Veiga-Crespo P
It exhibits a variety of biological activities
AES-350 - CAS# 847249-57-4 12841 Sirt2-PROTAC-1 is a SirReal basedAES 350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0. 0244 M and 0. 035 M, respectively. AES 350 is also against HDAC 3, 8, and 11 in an enzymatic activity assay with IC50 values of 0. 187 M, 0. 245 M, and >1M, respectively. AES 350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research. Product information CAS Number: 847249 57 4 Molecular Weight: 312. 36 Formula:
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