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whereas inhibits total SAPK/JNK activity with an IC50 of 3–10 μM
Chemical Name: (2S)-3-methoxy-2-[(2S)-3-methoxy-2-[(2-methyl-1
(2012) Anticancer Drugs
InChi: InChI=1S/C31H36N4O6
Chemical Name: (4Z)-cyclooct-4-en-1-yl N-[2-(2-{2-[2-({[(4Z)-cyclooct-4-en-1-yloxy]carbonyl}amino)ethoxy]ethoxy}ethoxy)ethyl]carbamate
EA4 Catalog No.:M22641-C whereas inhibits total SAPK/JNK activityKi: 130 M EA4 is a rPLA2 inhibitor. rPLA2, a calcium dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells. With a molecular mass of 42 kDa, cPLA2 shows biochemical properties similar to cPLA2 Type IV. In vitro: It was found that EA4 was able to inhibit a Ca(2+) ionophore induced arachidonic acid release from both human and bovine red blood cells, demonstrating that this enzyme was