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is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity
Aβ42-IN-1 free base potently reduces Aβ42 levels with an IC50 value of 0
CAS Number: 1011557-82-6
InChi: InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2
Smiles: COC1C=C(C(Cl)=CC=1)C1C=CC(NC(=O)C2=CC=NN2C)=NC=1N
SAR405 Size:Contact [email protected] for quotation is an orally available inhibitorSAR405 is a first in class, selective, and ATP competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1. 2 nM; Kd=1. 5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity. Product information CAS Number: 1523406 39 4 Molecular Weight: 443. 85 Formula: C19H21ClF3N5O2 Chemical Name: (2S) 1 [(5 chloropyridin 3 yl)methyl] 8 [(3R) 3 methylmorpholin 4 yl] 2 (trifluoromethyl) 1H,2H,3H,4H,6H
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