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2007 Oct 28
4-triazin-3-one
InChiKey: HFYMDQMXVPJNTH-VQHVLOKHSA-N
also known as DCC-270
Solubility: DMSO : 100 mg/mL (554
Losartan Carboxaldehyde 6681509 2007 Oct 28Losartan is an inhibitor of endothelial cyclooxygenase (COX) 2. COX 2 produces prostaglandins that inhibit apoptosis and stimulate angiogenesis and invasiveness, and thus selective COX 2 inhibitors can reduce prostaglandin synthesis and restore apoptosis. In vitro: Losartan is an intermediate aldehyde metabolite of losartan, the angiotensin II type 1 receptor antagonist. Losartan could not block angiotensin receptors, but inhibit the expression of
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