CEP-28122 mesylate salt Catalog No.:M20814-C Chemical Name: L-Alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-arginyl-L-lysyl-L-alanyl-L-leucyl-L-proline

Chemical Name: L-Alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-arginyl-L-lysyl-L-alanyl-L-leucyl-L-proline

67(7):1858-67

Tumor growth is inhibited by Ponatinib in a dose-dependent manner compare to vehicle-treated mice

In an intracellular Ca2+ (iCa2+) mobilization assay using HT29 colon cancer cells

73)74)35-45(49)57(2

CEP-28122 mesylate salt Catalog No.:M20814-C Chemical Name: L-Alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-arginyl-L-lysyl-L-alanyl-L-leucyl-L-prolineCEP 28122 mesylate salt, a diaminopyrimidine derivative, is a potent, selective, and orally bioavailable ALK inhibitor, with an IC50 value of 1. 9 nM for recombinant ALK kinase activity. CEP 28122 has antitumor activity in experimental models of ALK positive human cancers. CEP 28122 mesylate salt has good pharmacodynamic and pharmacokinetic activity. Product information CAS Number: 2070009 30 0 Molecular Weight: 635. 17 Formula: C29H39ClN6O6S Chemical