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3K/c2*7-3(8)1-6(13
Epub 2020 Mar 10
3-b]pyridazin-3-yl]sulfanyl}quinoline
Formula: C18H14ClN2NaO6S2
InChiKey: AMFDITJFBUXZQN-KUBHLMPHSA-N
AC710 mesylate eridol D4 3K/c2*7-3(8)1-6(13AC710 is a potent, orally active, and selective platelet derived growth factor receptor family kinase inhibitor with potential anticancer activity. Its IC50 values are 1. 2, 2, 7. 7 and 10. 5 nM for KIT, FLT3, PDGFR and CSF1R respectively; Kd = 1. 3 nM for PDGFR.. AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 also reduces joint swelling and inflammation in a mouse model of collagen induced arthritis. AC710 is now a
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