LEE011 succinate hydrate(1:1:x) Catalog No.:M9046-2 1080/01902148

1080/01902148

ML-329 could directly or indirectly interact with MITF or components of the MITF regulatory network

InChi: InChI=1S/C18H26N2O2/c1-14(2)17(18(22)20-12-6-7-13-20)19-16(21)11-10-15-8-4-3-5-9-15/h3-5

27-nonaen-4-yl]-N-methylbenzamide

is a selective VEGFR1 inhibitor

LEE011 succinate hydrate(1:1:x) Catalog No.:M9046-2 1080/01902148LEE011 succinate hydrate is an orally available cyclin dependent kinase (CDK) inhibitor targeting cyclin D1 CDK4 and cyclin D3 CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4 6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK mediated G1 S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing