Solasodine rolithin B Pimecrolimus blocks T-lymphocyte activation pathway

Pimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function

Smiles: NS(=O)(=O)C1C=CC(=CC=1)N1N=C(C=C1C1C=CC(Cl)=CC=1)C(F)(F)F

2010 Jan-Feb

Tagalakis AD

CN111320630A

Solasodine rolithin B Pimecrolimus blocks T-lymphocyte activation pathwaySolasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine reduces the mRNA level of matrix metalloproteinase 2 (MMP 2), MMP 9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion inducing cysteine rich protein with kazal motifs (RECK). Solasodine downregulates oncogenic microRNA 21