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It has IC50 < 0
Formula: C29H39N5O8
InChi: InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12
Minokoshi Y
EED inhibitor 1
Erastin xicillin Sodium It has IC50 < 0Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i. e. HRAS, KRAS). Erastin produces non apoptotic tumor cell death by altering mitochondrial voltage dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized
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