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PLX647 displayed minimal inhibition of the proliferation of Ba/F3 cells expressing BCR–KDR (IC50=5 μM)
O[C@H]1CCCN[C@@H]1CC(=O)CN1C=NC2=CC(Br)=C(Cl)C=C2C1=O
1038/s42003-018-0105-8
DTXSID80173463
of deubiquitinating enzyme (DUB) activity
SNS-314 Size:2mg solid PLX647 displayed minimal inhibition ofSNS 314 is a synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS 314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Product information CAS Number: 1057249 41 8
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