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J Clin Oncol
PubMed PMID: 27607364
ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model
1438492-26-2
Smiles: C[C@H](NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)NC1=CC=C(COC(=O)OC2C=CC(=CC=2)[N+]([O-])=O)C=C1
GNE-7915 - CAS# 1351761-44-8 0254 J Clin OncolGNE 7915, CAS No. 1351761 44 8, is a potent LRRK2 kinase inhibitor, which possess an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. GNE 7915 was reported as a potent (IC50=9 nM) selective (1 187 kinases), brain penetrant and non toxic inhibitor of LRRK2. Product information CAS Number: 1351761 44 8 Molecular Weight: 443. 40 Formula: C19H21F4N5O3 Synonym: GNE 7915