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Salovska B
21-11+/t26-/m0/s1
Molecular Weight: 393
5]oxadiazol-5-amine
InChiKey: PNYRDVBFYVDJJI-UHFFFAOYSA-N
CX-5461 - RNA Polymerase I inhibitor. CAS# 1138549-36-6 0179 Salovska BCX 5461, CAS No. 1138549 36 6, is a first in class non genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX 5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal