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GNE684 (20 μM
Spexin TFA attenuates LH secretion in goldfish
in liver cells and (ii) glutathione (GHS) conjugation
Formula: C31H32N4O3
InChi: InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31
Lesogaberan napadisylate - CAS# 477956-38-0 Catalog No.:M34969-C GNE684 (20 μMLesogaberan (AZD 3355) napadisylate is a potent and selective GABAB receptor agonist with an EC50 of 8. 6 nM for human recombinant GABAB receptors. The affinity (Kis) of Lesogaberan napadisylate for rat GABAB and GABAA receptors, as measured by displacement of [3H]GABA binding in brain membranes: 5. 1 nM and 1. 4 M, respectively. Lesogaberan napadisylate inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action.
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