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HFD mice have a marked increase in the number of F4/80 crown-like structures (+95%
Formula: C20H22N6OS2
Chemical Name: Desmethylglycitein
is a potent and selective antagonist of the G protein-coupled receptor identified as EBI2 (GPR183) (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors
whereas cytosolic fatty acid accumulates and glucose oxidation is elevated
Roscovitine (Seliciclib) D318088 HFD mice have a markedSeliciclib, also known as roscovitine and CYC202, is a n orally bioavailable, small molecule cyclin dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2 E, CDK2 A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK mediated phosphorylation of the carboxy terminal domain
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