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a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo
InChi: InChI=1S/C18H13ClFN3/c1-12-17(8-3-14-9-10-21-18(19)11-14)22-13(2)23(12)16-6-4-15(20)5-7-16/h4-7
MLN8237 is currently in Phase II study for treatment of patients with ovarian
InChiKey: SYENTKHGMVKGAQ-UHFFFAOYSA-N
4-triazol-1-yl)phenyl)acetamide
AG-221 (Enasidenib) - IHD2 Inhibitor. CAS# 1446502-11-9 size:Contact [email protected] for quotation a potent inhibitor of mitogen-activatedEnasidenib, also known as AG 221 and CC 90007, CAS No. 1446502 11 9, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH dependent reduction of ketoglutarate to R( ) 2 hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of
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