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PubMed Central PMCID: PMC5142825
PP-121 at a low concentration of 40 nM inhibits Ret autophosphorylation in TT thyroid carcinoma cells that express the C634W oncogenic Ret mutant35
Chemical Name: 3-(4-(3-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-N-(8-((2-(1-methyl-2
8-naphthyridine-1(2H)-carboxamide
Desai-Krieger D
AZD4547 ustat PubMed Central PMCID: PMC5142825AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation,