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Baricitinib - CAS# 1187594-09-7 dine HCl InChi: InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2

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Description

InChi: InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2

Appearance: Powder Solid

p32 Inhibitor M36 is selective for p32 overexpressing cells

Chemical Name: 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1

is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM

Baricitinib - CAS# 1187594-09-7 dine HCl InChi: InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2Baricitinib, CAS No. 1187594 09 7, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1 JAK2 inhibitor with nanomolar potency against JAK1 (5. 9 nM) and JAK2 (5. 7 nM). INCB028050 inhibits intracellular signaling of multiple proinflammatory cytokines including IL 6 and IL 23 at concentrations <50 nM. INCB028050 was also effective in multiple murine models of arthritis, with no evidence of suppression of humoral immunity or

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