FC 11 - CAS# 2271035-37-9 054 Hydrochloride 7S)-4-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-4-azatricyclo[5

7S)-4-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-4-azatricyclo[5

InChi: InChI=1S/C31H43FN8O3

Sodium naproxen

pii: S0190-9622(16)01507-3

10 and 30 mg/kg) significantly reduces ethanol intake relative to vehicle and does not effect water consumption in female P rats

FC 11 - CAS# 2271035-37-9 054 Hydrochloride 7S)-4-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-4-azatricyclo[5FC 11 is a highly potent focal adhesion kinase (FAK) PROTAC Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells. Product