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WT161 selectively inhibits HDAC6 and dramatically increases levels of acetylated α-tubulin (Ac-α-tubulin) with little effect on global lysine acetylation
69 L/kg and area under the concentration-time curve (AUC0-24 h) of 48 h•μg/mL
InChiKey: RYHCACJBKCOBTJ-UHFFFAOYSA-N
colony and tumorosphere forming capability in TNBC cells
Miridesap is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles
(S)-CFT7455 tinib bromide WT161 selectively inhibits HDAC6 and(S) CFT7455 is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader. (S) CFT7455 is an anti cancer agent that binds with high affinity to the cereblon E3 ligase (Kd of 0. 9 nM)(WO2022032132A1; Compound 1). Product information CAS Number: 2504235 67 8 Molecular Weight: 469. 53 Formula: C28H27N3O4 Smiles: O=C1CC[C@@H](C(=O)N1)N1C2=CC=C(CC3=CC=C(CN4CCOCC4)C=C3)C3=CC=CC(=C23)C1=O InChiKey: MUKCJOOKCZSQNW DEOSSOPVSA N