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Although MTH1 is non-essential in normal cells
Treshkur T
KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor
Formula: C27H28N2O3
Therefore KDM5-C70 was developed as a pro-drug
AI-10-49 - CAS# 1256094-72-0 60268 Although MTH1 is non-essential inAI 10 49, CAS No. 1256094 72 0, is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the
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