A-867744 - CAS# 1000279-69-5 terin) Smiles: CC(C)[C@@H](C(O)=O)N(CC1C=CC(=CC=1)C1=CC=CC=C1C1NN=NN=1)C(=O)CCCC

Smiles: CC(C)[C@@H](C(O)=O)N(CC1C=CC(=CC=1)C1=CC=CC=C1C1NN=NN=1)C(=O)CCCC

A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates

In vivo: The upper dose level for once-daily administration of CFI-402257 is between 6 and 6

CAS Number: 82-08-6

There is no formal name yet

A-867744 - CAS# 1000279-69-5 terin) Smiles: CC(C)[C@@H](C(O)=O)N(CC1C=CC(=CC=1)C1=CC=CC=C1C1NN=NN=1)C(=O)CCCCA 867744 is a type II PAM with good potency and selectivity. A 867744 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs. In a rodent model of sensory gating, A 867744 normalized gating deficits. A 867744 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs. A 867744 potentiated acetylcholine (ACh) evoked currents, with an EC(50) value of approximately 1