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InChi: InChI=1S/C22H24ClN7O/c1-24-21(31)17-4-2-3-5-19(17)28-20-18(23)14-26-22(29-20)27-15-6-8-16(9-7-15)30-12-10-25-11-13-30/h2-9
18550-98-6
Epub 2015 Mar 5
598-612 (2012)
Chemical Name: (3S
Fevipiprant - CAS# 872365-14-5 size:2mg solid InChi: InChI=1S/C22H24ClN7O/c1-24-21(31)17-4-2-3-5-19(17)28-20-18(23)14-26-22(29-20)27-15-6-8-16(9-7-15)30-12-10-25-11-13-30/h2-9Fevipiprant, CAS No. 872365 14 5, also known as NVP QAW039 or QAW039, is an oral active and potent CRTh2 receptor antagonist and potentially useful for asthma treatment. [(3)H] QAW039 displayed high affinity for the human CRTh2 receptor (1. 14 0. 44 nM) expressed in Chinese hamster ovary cells, the binding being reversible and competitive with the native agonist prostaglandin D2(PGD2). QAW039 was also a potent inhibitor of PGD2 induced cytokine
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