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In rabbit isolated ventricular myocytes
with IC50s of 18
and cynomolgus monkeys after oral administration
ion channels and 7-TM receptors
This causes global changes in protein acetylation and gene expression
Azidothymidine (AZT) - Reverse Transcriptase Inhibitor. CAS# 30516-87-1 Catalog No.:M60238-2S In rabbit isolated ventricular myocytesAzidothymidine (AZT), CAS No. 30516 87 1, is a selective, orally bioavailable and brain penetrant reverse transcriptase inhibitor. It has 100 fold selectivity for HIV reverse transcriptase over DNA polymerase . It can suppress HIV 1 replication and enhance cell viability in a HIV 1 infected T cell line. It can also suppress growth of a multiple myeloma (MM) cell line and reduces the growth of MM tumor xenografts in mice. In recent studies, AZT can
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