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ADC Toxin Monomethyl auristatin E (MMAE) - CAS# 474645-27-7 60023 In cellular assays ML141 inhibited

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Description

In cellular assays ML141 inhibited Cdc42-related filopodia formation and cell migration

InChi: InChI=1S/C27H36N4O5S/c1-6-37(34

Felletar I

ATB-346 exerts superior chemopreventive effects to those of naproxen

including the pupillary light reflex and light aversion

ADC Toxin Monomethyl auristatin E (MMAE) - CAS# 474645-27-7 60023 In cellular assays ML141 inhibitedMonomethyl auristatin E (MMAE, vedotin), CAS No. 474645 27 7, is a very potent anti mitotic agent that inhibits cell division by blocking the polymerisation of tubulin. Because of ts super toxicity, it cannot be used as a drug itself. In recent cancer therapy developments, it is linked to a monoclonal antibody (mAb) that recognizes a pecific marker expression in cancer cells and directs MMAE to the cancer cells. The linker linking MMAE to the

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