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Smiles: ONC(=O)CCC1=CC=C(CN[C@@H](C2CCCCC2)C(=O)OC2CCCC2)C=N1
LY-3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro
which binds to the HM/PIF binding pocket rather than the ATP-binding site
DU-145 prostate cancer
Epub 2019 May 29
PAI-039 - CAS# 393105-53-8 size:2mg solid Smiles: ONC(=O)CCC1=CC=C(CN[C@@H](C2CCCCC2)C(=O)OC2CCCC2)C=N1PAI 039, CAS No. 393105 53 8, is a novel plasminogen activator inhibitor 1 (PAI 1) inhibitor. The pharmacokinetic profile of PAI 039 indicated an oral bioavailability of 43 + 15. 3% and a plasma half life of 6. 2 + 1. 3 h. PAI 039 is an orally active prothrombolytic drug that inhibits PAI 1 and accelerates fibrinolysis while maintaining normal coagulation in a model of coronary occlusion . PAI 039 exerts antithrombotic efficacy in rat models of
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