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Structural and mechanistic insights into nuclear transport and delivery of the critical pluripotency factor Oct4 to DNA
Daily HepG2 tumor growth of WAY-600-administrated mice is significantly lower than that of vehicle control mice
is rapidly cleaved to release the active form Olmesartan (RNH-6270)
Cilomilast reduces TLR4 expression
Formula: C26H28N8O
Fedratinib hydrochloride hydrate ((2S)-1 2-propanediol hydrate) Structural and mechanistic insights intoFedratinib hydrochloride hydrate (TG 101348 hydrochloride hydrate) is a potent, selective, ATP competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35 and 334 fold selectivity over JAK1 and JAK3, respectively. Fedratinib hydrochloride hydrate induces cancer cell apoptosis and has the potential for myeloproliferative disorders research. Product information CAS Number: