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SB-743921 overcomes imatinib resistance in CML cells
3)19-11-13-20(14-12-19)29(24(31)21-10-8-16-32-21)22(18-9-7-15-27-17-18)23(30)28-26(4
2*2-1(3)4/h3-18H
31)28-13-12-20-24(15-29)27-23-11-8-17(14-21(23)25(20)28)19-4-2-3-5-22(19)26/h2-11
Yamashita Y
UPF-648 Sodium Salt 436 SB-743921 overcomes imatinib resistance inUPF 648 is a potent kynurenine 3 monooxygenase (KMO) inhibitor; exhibits highly active at 1 uM (81 10% KMO inhibition); ineffective at blocking KAT activity. IC50 value: 1 uM(81 10 % inhibition) Target: KMO inhibitor in vitro: BFF 122 inhibited KAT activity almost completely at both 1 and 0. 1 mM. The effect was still remarkable at 0. 01 mM (70 1 % inhibition). Product information CAS Number: 1465017 87 1 Molecular Weight: 281. 07 Formula:
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