CCG-1423 Catalog No.:M9362-10 Chemical Name: 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine

Chemical Name: 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine

5-bis[(thiophen-2-yl)methylidene]cyclopentan-1-one

MLN-9708 inhibits the invasion ability of MG-63 and Saos-2 cells and decreases both the expression and secretion levels of MMP2/9

5S)-2-(hydroxymethyl)-1

which suggests a positive impact of the HDAC inhibitor on pulmonary vascular remodeling and stiffening

CCG-1423 Catalog No.:M9362-10 Chemical Name: 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamineCCG 1423 is a small molecule inhibitor of RhoA transcriptional signaling. CCG 1423 displays activity in several in vitro cancer cell functional assays. CCG 1423 potently (<1 mumol L) inhibits lysophosphatidic acid induced DNA synthesis in PC 3 prostate cancer cells, and whereas it inhibits the growth of RhoC overexpressing melanoma lines (A375M2 and SK Mel 147) at nanomolar concentrations, it is less active on related lines (A375 and SK Mel 28) that