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RPPA data shows that Defactinib reduces levels of AKT and YB-1 in taxane-resistant cell lines
C6H8O7/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16
The NRTIs lamivudine
treatment with AMG 510 resulted in a pro-inflammatory tumour microenvironment and produced durable cures alone as well as in combination with immune-checkpoint inhibitors
Smiles: COC1C=C2C3C(NC2=CC=1C1=C(C)ON=C1C)=NC(=NC=3NC1=CC(=NN1CC)C1CC1)C(=O)NCCCC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O
(S, R, S)-AHPC-C1-Br Catalog No.:M13078-2 RPPA data shows that Defactinib(S,R,S) AHPC C1 Br is a synthesized E3 ligase ligand linker conjugate that incorporates the (S,R,S) AHPC based VHL ligand and a linker used in PROTAC technology. Product information CAS Number: 2379404 33 6 Molecular Weight: 551. 50 Formula: C24H31BrN4O4S Chemical Name: (2S,4R) 1 [(2S) 2 (2 bromoacetamido) 3,3 dimethylbutanoyl] 4 hydroxy N {[4 (4 methyl 1,3 thiazol 5 yl)phenyl]methyl}pyrrolidine 2 carboxamide Smiles:
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