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Formula: C27H38N8O
CAS Number: 10017-44-4
trifluoromethyloxadiazole (TFMO)
and does not significantly inhibit LRRK2 even at doses as high as 30 μM (500-fold higher than IC50 of inhibition of ROCK2)
GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro
MK-1064 R501 Formula: C27H38N8OMK 1064 is a selective orexin 2 receptor antagonist (2 SORA) for the research of insomnia. target: 2 SORA In vivo: MK 1064 promotes sleep and increases both rapid eye movement (REM) and non REM (NREM) sleep in rats at OX2R occupancies higher than the range observed for dual orexin receptor antagonists. MK 1064 increases NREM and REM sleep in dogs without inducing cataplexy. The reference for animal administration is 30 mg kg. Product information CAS