YS-121 AC for CDK6 and ovine luminal endometrial cell

and ovine luminal endometrial cell lines relative to the vehicle-treated cells

Natthinee Anantachoke

InChi: InChI=1S/C60H101N15O17/c1-9-31(4)44(54(86)69-41(29-36-19-13-12-14-20-36)52(84)70-45(32(5)10-2)55(87)72-46(59(91)92)33(6)11-3)71-57(89)48(35(8)78)73-51(83)38(21-15-16-26-61)66-50(82)39(24-25-43(79)80)67-56(88)47(34(7)77)74-53(85)42-23-18-28-75(42)58(90)40(22-17-27-65-60(63)64)68-49(81)37(62)30-76/h12-14

CAS Number: 59870-65-4

78 nM and 18

YS-121 AC for CDK6 and ovine luminal endometrial cellYS 121 is a dual inhibitor of Microsomal prostaglandin E2 synthase 1 (mPGES 1) . Cyclooxygenases (COX 1 and COX 2) have been involved in catalyzing the formation of prostaglandins and related eicosanoids and play an essential role in the pathogenesis of breast cancer. Actions of COX 2 are mediated by prostaglandin E2 (PGE2). Microsomal PGES 1 (mPGES 1), the inducible form of PGES, has a marked affinity for coupling with COX 2. Expression of mPGES 1