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2008 Nov 13
39(6):603-5
for 1 hour) attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4
used to treat tuberculosis
CSF1R) (IC50 values are 2
BMS-833923 - CAS# 1059734-66-5 Size:Solid 10 mg 2008 Nov 13BMS 833923, also known as XL 139, is an orally bioavailable small molecule SMO (Smoothened) inhibitor with potential antineoplastic activity. SMO antagonist BMS 833923 inhibits the sonic hedgehog (SHH) pathway protein SMO, which may result in a suppression of the SHH signaling pathway. SMO is a G protein coupled receptor that lies just downstream of the SHH ligand cell surface receptor Patched 1 in the SHH pathway; in the absence of ligand Patched 1
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