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71(6):453-62
Eiermann G
4)35(39)23(17-41(26
3-dihydro-1H-inden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl}amino)phenyl]formamido}ethoxy)ethoxy]ethoxy}propanamide
Formula: C14H14Cl3O6P
VAL-083 - CAS# 23261-20-3 inone I 71(6):453-62VAL 083 is a bi functional alkylating agent, with potential antineoplastic activity. Upon administration, VAL 083 crosses the blood brain barrier (BBB) and appears to be selective for tumor cells. This agent alkylates and crosslinks DNA which ultimately leads to a reduction in cancer cell proliferation. In addition, VAL 083 does not show cross resistance to other conventional chemotherapeutic agents and has a long half life in the brain. Product
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