LY2603618 Catalog No.:M10749-2 Mice treated orally with 10

Mice treated orally with 10 mg CZC24832 per kg body weight twice per day show a substantial decrease of bone and cartilage destruction (53% reduction by histopathological analysis) as well as of overall clinical parameters (38% reduction)

Christopher J

InChiKey: GGQCIOOSELPMBB-UHFFFAOYSA-N

6(6):540-6

14(9):1061-9

LY2603618 Catalog No.:M10749-2 Mice treated orally with 10Rabusertib, also known as LY2603618, is a n inhibitor of the cell cycle checkpoint kinase 2 (chk2) with potential chemopotentiating activity. Rabusertib binds to and inhibits the activity of chk2, which may prevent the repair of DNA caused by DNA damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk2, an ATP dependent serine threonine kinase, is a key component in the DNA replication monitoring checkpoint