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15-tetramethyltetracyclo[8
WO2020002969A1
3)29-22(24)20-28-18-17-26-16-15-25-13-9-4-5-10-14-27-19-21-11-7-6-8-12-21/h6-8
with 40x selectivity over 5-HT2C
Monensin is an ionophore related to the crown ethers with a preference to form complexes with monovalent cations such as: Li+
BS-181 dihydrochloride enzamine Hydrochloride 15-tetramethyltetracyclo[8BS 181 dihydrochloride is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY 30237). BS 181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880 nM, 3000 nM and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS 181 dihydrochloride inhibits a panel of cancer cells growth (IC50=11. 5 M 37. 3 M) and induces cell apoptosis. BS 181 dihydrochloride has the potential for the research of cancer therapy. Product information
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