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CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM
In the HT29 and in the COLO 205 colon carcinoma models
9 mg/kg per day for 14 days
1 μM) inhibits EGFR potently and irreversibly
Formula: C31H32N6O2
AC220 - CAS# 950769-58-1 071 CAY10603 has potent antiproliferative activityQuizartinib, also know as AC220 and AC010220, CAS No. 950769 58 1, is an orally available FLT3 STK1 inhibitor with potential antineoplastic activity. Class III receptor tyrosine kinase inhibitor AC220 selectively inhibits class III receptor tyrosine kinases, including FMS related tyrosine kinase 3 (FLT3 STK1), colony stimulating factor 1 receptor (CSF1R FMS), stem cell factor receptor (SCFR KIT), and platelet derived growth factor receptors (PDGFRs),
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